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Vaccine Detail
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Ebola virus recombinant VSVΔG-GP encoding GP |
| Vaccine Information |
- Vaccine Name: Ebola virus recombinant VSVΔG-GP encoding GP
- Target Pathogen: Ebola virus
- Target Disease: Ebola hemorrhagic fever
- Vaccine Ontology ID: VO_0004336
- Type: Recombinant vector vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Macaque
- GP from Zaire ebolavirus
gene engineering:
- Type: Recombinant vector construction
- Description: Vector VSVΔG expressed GP from ZEBOV (Jones et al., 2005).
- Detailed Gene Information: Click Here.
- Vector:
- Vector name:
- VO vector ID: VO_0001025
- Description: This vaccine uses a replication competent vesicular stomatitis virus vector (VSV?G) (Jones et al., 2005)
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Macaque Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: A single intramuscular injection of the EBOV or MARV vaccine elicited completely protective immune responses in nonhuman primates against lethal EBOV or MARV challenges (Jones et al., 2005).
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| References |
Jones et al., 2005: Jones SM, Feldmann H, Ströher U, Geisbert JB, Fernando L, Grolla A, Klenk HD, Sullivan NJ, Volchkov VE, Fritz EA, Daddario KM, Hensley LE, Jahrling PB, Geisbert TW. Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses. Nature medicine. 2005; 11(7); 786-790. [PubMed: 15937495].
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