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Vaccine Detail
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Ebola virus recombinant rAD-GP encoding GP |
| Vaccine Information |
- Vaccine Name: Ebola virus recombinant rAD-GP encoding GP
- Target Pathogen: Ebola virus
- Target Disease: Ebola hemorrhagic fever
- Vaccine Ontology ID: VO_0004335
- Type: Recombinant vector vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Macaque
- GP from Zaire ebolavirus
gene engineering:
- Type: Recombinant vector construction
- Description: Vector rAd expressed the Ebola glycoprotein (GP) (Sullivan et al., 2006).
- Detailed Gene Information: Click Here.
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Macaque Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Expression of specific GPs alone vectored by rAd are sufficient to confer protection against lethal challenge in a relevant nonhuman primate model (Sullivan et al., 2006).
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| References |
Sullivan et al., 2006: Sullivan NJ, Geisbert TW, Geisbert JB, Shedlock DJ, Xu L, Lamoreaux L, Custers JH, Popernack PM, Yang ZY, Pau MG, Roederer M, Koup RA, Goudsmit J, Jahrling PB, Nabel GJ. Immune protection of nonhuman primates against Ebola virus with single low-dose adenovirus vectors encoding modified GPs. PLoS medicine. 2006; 3(6); e177. [PubMed: 16683867].
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