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Vaccine Detail
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Ebola virus DNA vaccine GP DNA |
| Vaccine Information |
- Vaccine Name: Ebola virus DNA vaccine GP DNA
- Target Pathogen: Ebola virus
- Target Disease: Ebola hemorrhagic fever
- Vaccine Ontology ID: VO_0004334
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- GP from Zaire ebolavirus
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pWRG7077 expressed highly glycosylated type 1 transmembrane protein (GP) (Vanderzanden et al., 1998).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000346
- Immunization Route: PowderJect-XR gene gun
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Mice were completely protected from challenge with mouse adapted EBOV with a priming dose of 0.5 microgram of GP DNA followed by three or four subsequent vaccinations with 1.5 micrograms of DNA. Partial protection could be observed for at least 9 months after three immunizations with 0.5 microgram of the GP DNA vaccine (Vanderzanden et al., 1998).
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| References |
Vanderzanden et al., 1998: Vanderzanden L, Bray M, Fuller D, Roberts T, Custer D, Spik K, Jahrling P, Huggins J, Schmaljohn A, Schmaljohn C. DNA vaccines expressing either the GP or NP genes of Ebola virus protect mice from lethal challenge. Virology. 1998 Jun 20; 246(1); 134-44. [PubMed: 9657001].
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