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Vaccine Detail
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Human papillomavirus DNA vaccine VlJns-Ll encoding L1 |
| Vaccine Information |
- Vaccine Name: Human papillomavirus DNA vaccine VlJns-Ll encoding L1
- Target Pathogen: Human Papillomavirus
- Target Disease: HPV infection
- Vaccine Ontology ID: VO_0004328
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Rabbit
- L1 HPV 16
gene engineering:
- Type: DNA vaccine construction
- Description: Vector VlJns expressed the major viral capsid protein L1 (Donnelly et al., 1996).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0005044
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Rabbit Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Immunization with plasmid DNA encoding L1 elicited conformationally specific neutralizing antibodies and provided immunity against papilloma formation upon challenge with CRPV (Donnelly et al., 1996).
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| References |
Donnelly et al., 1996: Donnelly JJ, Martinez D, Jansen KU, Ellis RW, Montgomery DL, Liu MA. Protection against papillomavirus with a polynucleotide vaccine. The Journal of infectious diseases. 1996; 173(2); 314-320. [PubMed: 8568291].
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