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Vaccine Detail
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Newcastle disease virus DNA vaccine pCAGF encoding the F protein |
| Vaccine Information |
- Vaccine Name: Newcastle disease virus DNA vaccine pCAGF encoding the F protein
- Target Pathogen: Newcastle disease virus
- Target Disease: Newcastle disease
- Vaccine Ontology ID: VO_0004324
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Chicken
- F fusion protein
gene engineering:
- Type: DNA vaccine construction
- Description: Vector Pcaggs expressed the Newcastle disease virus Fprotein (NDV-F) (Sakaguchi et al., 1996).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000099
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Chicken Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: At 9 weeks post-injection, chickens were challenged with the velogenic NDV Sato strain. The chickens that had the antibody against NDV-F from immunization were protected from lethal NDV challenge. The DNA vaccine conferred efficient protection against the disease (Sakaguchi et al., 1996).
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| References |
Sakaguchi et al., 1996: Sakaguchi M, Nakamura H, Sonoda K, Hamada F, Hirai K. Protection of chickens from Newcastle disease by vaccination with a linear plasmid DNA expressing the F protein of Newcastle disease virus. Vaccine. 1996; 14(8); 747-752. [PubMed: 8817820].
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