• Vaccine Name: Foot and mouth disease DNA vaccine pWRMHX encoding a minimal self-cleaving ribozyme
• Target Pathogen: Foot-and-mouth disease virus
• Target Disease: Foot-and-mouth disease
• Vaccine Ontology ID: VO_0004320
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse, pig
• FMDV A12 genome gene engineering:
  • Type: DNA vaccine construction
  • Description: This vaccine encoded the genome of FMDV strain A12 and a minimal self-cleaving ribozyme from hepatitis delta virus (Ward et al., 1997),
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000353
• Immunization Route: Intramuscular injection (i.m.)

Pig Response

• Vaccine Immune Response Type: VO_0000286
• Efficacy: Swine inoculated with pWRMHX did not show any signs of disease and produced neutralizing antibodies to FMDV, and 20% of the vaccinated animals were protected from FMDV challenge (Ward et al., 1997).