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Vaccine Detail
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Foot and mouth disease DNA vaccine pWRMHX encoding a minimal self-cleaving ribozyme |
| Vaccine Information |
- Vaccine Name: Foot and mouth disease DNA vaccine pWRMHX encoding a minimal self-cleaving ribozyme
- Target Pathogen: Foot-and-mouth disease virus
- Target Disease: Foot-and-mouth disease
- Vaccine Ontology ID: VO_0004320
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse, pig
- FMDV A12 genome
gene engineering:
- Type: DNA vaccine construction
- Description: This vaccine encoded the genome of FMDV strain A12 and a minimal self-cleaving ribozyme from hepatitis delta virus (Ward et al., 1997),
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid: pWRM DNA vaccine plasmid
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Pig Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Swine inoculated with pWRMHX did not show any signs of disease and produced neutralizing antibodies to FMDV, and 20% of the vaccinated animals were protected from FMDV challenge (Ward et al., 1997).
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| References |
Ward et al., 1997: Ward G, Rieder E, Mason PW. Plasmid DNA encoding replicating foot-and-mouth disease virus genomes induces antiviral immune responses in swine. Journal of virology. 1997; 71(10); 7442-7447. [PubMed: 9311823].
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