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Vaccine Detail
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Bovine herpesvirus 1 DNA vaccine pMASIAtgB encoding a truncated, secreted form of gB |
| Vaccine Information |
- Vaccine Name: Bovine herpesvirus 1 DNA vaccine pMASIAtgB encoding a truncated, secreted form of gB
- Target Pathogen: Bovine herpesvirus 1
- Target Disease: Infectious bovine rhinotracheitis
- Vaccine Ontology ID: VO_0004317
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mice, calves
- gB
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pMASIA expressed truncated, secreted form of BHV-1 gB (Huang et al., 2005).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid: pMASIA DNA vaccine plasmid
- Immunization Route: Intraperitoneal injection (i.p.)
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| Host Response |
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Cattle Response
- Vaccine Immune Response Type: VO_0000286
- Immune Response: pMASIAtgB elicited both humoral responses and activated gamma interferon-secreting CD8+ CTLs, suggesting that a DNA vaccine expressing tgB induces a CTL response in the natural host of BHV-1 (Huang et al., 2005).
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| References |
Huang et al., 2005: Huang Y, Babiuk LA, van Drunen Littel-van den Hurk S. Immunization with a bovine herpesvirus 1 glycoprotein B DNA vaccine induces cytotoxic T-lymphocyte responses in mice and cattle. The Journal of general virology. 2005; 86(Pt 4); 887-898. [PubMed: 15784883].
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