• Vaccine Name: Bovine herpesvirus 1 DNA vaccine pRSVgIV
• Target Pathogen: Bovine herpesvirus 1
• Target Disease: Infectious bovine rhinotracheitis
• Vaccine Ontology ID: VO_0004315
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse, calf
• gIV gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector pRSV expressed BHV-1 glycoprotein I (gIV) (Cox et al., 1993).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000305
• Immunization Route: Intramuscular injection (i.m.)

Cattle Response

• Vaccine Immune Response Type: VO_0000286
• Efficacy: Clinical symptoms including fever, nasal mucosal lesions, and inappetence were reduced in all pRSVgIV-injected calves compared with the pRSVO-injected calf (control). Increases in gIV-specific antibody titers were observed at day 6 post challenge and continued to the end of the experiment. By comparison with the titer achieved by the control calf after challenge, it is clear that all three pRSVgIV-injected calves were primed to respond to BHV-1 (Cox et al., 1993).