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Vaccine Detail

Bovine herpesvirus 1 DNA vaccine pRSVgIV
Vaccine Information
  • Vaccine Name: Bovine herpesvirus 1 DNA vaccine pRSVgIV
  • Target Pathogen: Bovine herpesvirus 1
  • Target Disease: Infectious bovine rhinotracheitis
  • Vaccine Ontology ID: VO_0004315
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse, calf
  • gIV gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pRSV expressed BHV-1 glycoprotein I (gIV) (Cox et al., 1993).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid:
    • DNA vaccine plasmid name:
    • DNA vaccine plasmid VO ID: VO_0000305
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Cattle Response

  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: Clinical symptoms including fever, nasal mucosal lesions, and inappetence were reduced in all pRSVgIV-injected calves compared with the pRSVO-injected calf (control). Increases in gIV-specific antibody titers were observed at day 6 post challenge and continued to the end of the experiment. By comparison with the titer achieved by the control calf after challenge, it is clear that all three pRSVgIV-injected calves were primed to respond to BHV-1 (Cox et al., 1993).
References
Cox et al., 1993: Cox GJ, Zamb TJ, Babiuk LA. Bovine herpesvirus 1: immune responses in mice and cattle injected with plasmid DNA. Journal of virology. 1993; 67(9); 5664-5667. [PubMed: 8350420].