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Vaccine Detail
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Influenza virus DNA vaccine HA DNA |
| Vaccine Information |
- Vaccine Name: Influenza virus DNA vaccine HA DNA
- Target Pathogen: Influenza virus
- Target Disease: Influenza (flu)
- Vaccine Ontology ID: VO_0004309
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- HA
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pCAGGSP7 expressed the viral surface glycoproteins (HA)of A/PR/8/34 (PR8, H1N1) influenza virus (Chen et al., 1999).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0005000
- Immunization Route: Gene gun
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| Host Response |
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Mouse Response
- Host Strain: BALB/c
- Vaccination Protocol: Mice were inoculated with each DNA construct twice, 3 weeks apart, at a dose of 1 microg per mouse by particle-mediated DNA transfer (gene gun) to the epidermis (Chen et al., 1999).
- Vaccine Immune Response Type: VO_0000286
- Challenge Protocol: Mice were challenged with a lethal dose of the homologous virus 7 days after the second vaccination (Chen et al., 1999).
- Efficacy: HA-DNA afforded significant protection only in BALB/c mice (Chen et al., 1999)
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| References |
Chen et al., 1999: Chen Z, Yoshikawa T, Kadowaki S, Hagiwara Y, Matsuo K, Asanuma H, Aizawa C, Kurata T, Tamura S. Protection and antibody responses in different strains of mouse immunized with plasmid DNAs encoding influenza virus haemagglutinin, neuraminidase and nucleoprotein. The Journal of general virology. 1999; 80 ( Pt 10); 2559-2564. [PubMed: 10573147].
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