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Vaccine Detail
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Influenza virus DNA vaccine pBK-SFV-NP |
| Vaccine Information |
- Vaccine Name: Influenza virus DNA vaccine pBK-SFV-NP
- Target Pathogen: Influenza virus
- Target Disease: Influenza (flu)
- Vaccine Ontology ID: VO_0004303
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- NP from Influenza A virus (A/Puerto Rico/8/34(H1N1))
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pBK-SFV expressed influenza nucleoprotein(NP) (Berglund et al., 1998).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000080
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Immunized animals acquired protective immunity to lethal influenza challenge. Five of seven immunized mice survived viral challenge, compared to one of four surviving mice in the saline-immunized control group (Berglund et al., 1998).
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| References |
Berglund et al., 1998: Berglund P, Smerdou C, Fleeton MN, Tubulekas I, Liljeström P. Enhancing immune responses using suicidal DNA vaccines. Nature biotechnology. 1998; 16(6); 562-565. [PubMed: 9624688].
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