• Vaccine Name: Influenza virus DNA vaccine pHA/NP147–155 encoding NP147-155
• Target Pathogen: Influenza virus
• Target Disease: Influenza (flu)
• Vaccine Ontology ID: VO_0004302
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• NP gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector pVAX1 expressed nucleoprotein (NP) specific CTL epitope (NP147–155) (Tao et al., 2009).
  • Detailed Gene Information: Click Here.
• HA gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector pVAX1 expressed surface proteins hemagglutinin (HA) (Tao et al., 2009).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000024
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccine Immune Response Type: VO_0000286
• Efficacy: Mice vaccinated with pHA/NP147–155 had significantly reduced lung viral titers, compared with control mice vaccinated with the pVAX1vector. Our data showed that vaccination of mice with pHA/NP147–155 induced the enhanced protection against H5N1 influenza virus infection in BALB/c mice, suggesting that it is feasible to use DNA vaccines that express multiple epitopes to fight against H5N1 influenza viruses. the enhanced protection against the H5N1 influenza virus by pHA/NP147–155 vaccination was dependent on the recognition of the H-2d dominant CD8+ T cell epitope in mice (Tao et al., 2009).