|
|
Vaccine Detail
|
Influenza virus DNA vaccine pRSV-NP encoding the coding sequence from influenza virus A/PR/8/34. |
| Vaccine Information |
- Vaccine Name: Influenza virus DNA vaccine pRSV-NP encoding the coding sequence from influenza virus A/PR/8/34.
- Target Pathogen: Influenza virus
- Target Disease: Influenza (flu)
- Vaccine Ontology ID: VO_0004301
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- NP from Influenza A virus (A/Puerto Rico/8/34(H1N1))
gene engineering:
- Type: DNA vaccine construction
- Description: Vector Rous sarcoma virus expressed the nucleoprotein (Raz et al., 1994).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000305
- Immunization Route: Intramuscular injection (i.m.)
|
| Host Response |
|
Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Five of the i.d. vaccinated mice (vaccinated with pRSV-NP), but only one of the control mice, survived influenza infection (Raz et al., 1994).
|
| References |
Raz et al., 1994: Raz E, Carson DA, Parker SE, Parr TB, Abai AM, Aichinger G, Gromkowski SH, Singh M, Lew D, Yankauckas MA. Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses. Proceedings of the National Academy of Sciences of the United States of America. 1994; 91(20); 9519-9523. [PubMed: 7937799].
|
|
