|
|
Vaccine Detail
|
Influenza virus DNA vaccine pIRES/HA/IL-2 expressing HA |
| Vaccine Information |
- Vaccine Name: Influenza virus DNA vaccine pIRES/HA/IL-2 expressing HA
- Target Pathogen: Influenza virus
- Target Disease: Influenza (flu)
- Vaccine Ontology ID: VO_0004296
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- HA
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pIRES expressed surface proteins hemagglutinin (HA) (Henke et al., 2006).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000262
- Immunization Route: Intramuscular injection (i.m.)
|
| Host Response |
|
Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Two inoculations of pIRES/HA/IL-2 protected 83.33% of mice against lethal influenza challenge (Henke et al., 2006).
|
| References |
Henke et al., 2006: Henke A, Rohland N, Zell R, Wutzler P. Co-expression of interleukin-2 by a bicistronic plasmid increases the efficacy of DNA immunization to prevent influenza virus infections. Intervirology. 2006; 49(4); 249-252. [PubMed: 16601357].
|
|
