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Vaccine Detail
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Influenza virus DNA vaccine pCMV/Hl encoding H1 |
| Vaccine Information |
- Vaccine Name: Influenza virus DNA vaccine pCMV/Hl encoding H1
- Target Pathogen: Influenza virus
- Target Disease: Influenza (flu)
- Vaccine Ontology ID: VO_0004292
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- HA
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pCMV expressed influenza virus hemagglutinin subtype 1 (H1) glycoproteins (Fynan et al., 1993).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000215
- Immunization Route: Gene gun epidermis delivery
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: In mice, 95% protection was achieved by two immunizations with beads loaded with as little as 0.4 micrograms of DNA (Fynan et al., 1993).
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| References |
Fynan et al., 1993: Fynan EF, Webster RG, Fuller DH, Haynes JR, Santoro JC, Robinson HL. DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations. Proceedings of the National Academy of Sciences of the United States of America. 1993; 90(24); 11478-11482. [PubMed: 8265577].
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