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Vaccine Detail
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Influenza virus DNA vaccine p188 encoding H7 |
| Vaccine Information |
- Vaccine Name: Influenza virus DNA vaccine p188 encoding H7
- Target Pathogen: Influenza virus
- Target Disease: Influenza (flu)
- Vaccine Ontology ID: VO_0004291
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Chicken
- HA
gene engineering:
- Type: DNA vaccine construction
- Description: Vector p188 expressed a replication-defective derivative of avian leucosis virus that expresses the haemagglutinin type 7 (HT) gene of A/Seal/Mass/I/80 (H7N7) (Robinson et al., 1993).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0005007
- Immunization Route: Intraperitoneal injection (i.p.)
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| Host Response |
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Chicken Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: In a series of four experiments, 50% (28/56) of the DNA-vaccinated and < 2% (1/67) of the control chickens survived the challenge (Robinson et al., 1993).
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| References |
Robinson et al., 1993: Robinson HL, Hunt LA, Webster RG. Protection against a lethal influenza virus challenge by immunization with a haemagglutinin-expressing plasmid DNA. Vaccine. 1993; 11(9); 957-960. [PubMed: 8212843].
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