• Vaccine Name: Influenza virus DNA vaccine BacPAKHA encoding EqfKY HA
• Target Pathogen: Influenza virus
• Target Disease: Influenza (flu)
• Vaccine Ontology ID: VO_0004290
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• HA gene engineering:
  • Type: DNA vaccine construction
  • Description: The EqfKY HA, hemagglutinin(HA) of a prototypical equine influenza virus was inserted into vector pBacPAK9 (Olsen et al., 1997).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000039
• Immunization Route: Gene gun

Mouse Response

• Host Strain: BALB/c
• Vaccine Immune Response Type: VO_0000286
• Efficacy: When two doses of DNA vaccine were administered 3 weeks apart, mice were not protected from challenge, although they cleared the infection more rapidly than control mice. However, when the second DNA vaccination was delayed until 9 weeks after the first, 9 out of 10 vaccinated mice were completely protected (Olsen et al., 1997).