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Vaccine Detail
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Bovine Respiratory Syncytial Virus recombinant vector vaccine BHVl/BRSVG encoding the G protein |
| Vaccine Information |
- Vaccine Name: Bovine Respiratory Syncytial Virus recombinant vector vaccine BHVl/BRSVG encoding the G protein
- Target Pathogen: Bovine Respiratory Syncytial Virus
- Target Disease: Respiratory Disease
- Vaccine Ontology ID: VO_0004289
- Type: Recombinant vector vaccine
- Status: Licensed
- Host Species as Laboratory Animal Model: Calves
- glycoprotein G
gene engineering:
- Type: Recombinant vector construction
- Description: The gE gene was replaced by a gene encoding the G protein of BRSV in a BHVI vector (Schrijver et al., 1997).
- Detailed Gene Information: Click Here.
- Immunization Route: intranasal immunization
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| Host Response |
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Cattle Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Flow cytometric analysis showed a significant relative increase of gamma/delta+ T cells in peripheral blood after BRSV challenge-infection of the calves of the control group but not in the vaccinated groups. These results indicate that the G protein of BRSV can induce significant protection against BRSV infection in cattle, and that the BHV1/BRSV-G vaccine protects effectively against a subsequent BRSV and BHV1 infection (Schrijver et al., 1997).
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| References |
Schrijver et al., 1997: Schrijver RS, Langedijk JP, Keil GM, Middel WG, Maris-Veldhuis M, Van Oirschot JT, Rijsewijk FA. Immunization of cattle with a BHV1 vector vaccine or a DNA vaccine both coding for the G protein of BRSV. Vaccine. 1997; 15(17-18); 1908-1916. [PubMed: 9413101].
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