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Vaccine Detail

Brucella abortus S19 vjbR mutant vaccine
Vaccine Information
  • Vaccine Name: Brucella abortus S19 vjbR mutant vaccine
  • Target Pathogen: Brucella spp.
  • Target Disease: Brucellosis
  • Vaccine Ontology ID: VO_0004283
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • vjbR gene engineering:
    • Type: Gene mutation
    • Description: The vjbR was mutated in Brucella abortus strain 19 (Arenas-Gamboa et al., 2009).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intraperitoneal injection (i.p.)
Host Response

Mouse Response

  • Persistence: An encapsulated vjbR mutant is attenuated in mice (Arenas-Gamboa et al., 2009).
  • Efficacy: A single dose of an encapsulated vjbR mutant induced protection in mice from challenge with wild type Brucella (Arenas-Gamboa et al., 2009).
  • Host Ighg1 response
    • Description: Mouse immunization with encapsulated S19 ΔvjbR::Kan induced higher IgG1 and IgG2a levels compared to the nonencapsulated S19 ΔvjbR::Kan mutant 3 weeks post vaccination and significantly higher levels than naive mice (Arenas-Gamboa et al., 2009).
    • Detailed Gene Information: Click Here.
  • Host Ighv1-9 response
    • Description: Mouse immunization with encapsulated S19 ΔvjbR::Kan induced higher IgG1 and IgG2a levels compared to the nonencapsulated S19 ΔvjbR::Kan mutant 3 weeks post vaccination and significantly higher levels than naive mice (Arenas-Gamboa et al., 2009).
    • Detailed Gene Information: Click Here.
References
Arenas-Gamboa et al., 2009: Arenas-Gamboa AM, Ficht TA, Kahl-McDonagh MM, Gomez G, Rice-Ficht AC. The Brucella abortus S19 DeltavjbR live vaccine candidate is safer than S19 and confers protection against wild-type challenge in BALB/c mice when delivered in a sustained-release vehicle. Infection and immunity. 2009; 77(2); 877-884. [PubMed: 19047401].