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Vaccine Detail
Brucella abortus S19 vjbR mutant vaccine |
Vaccine Information |
- Vaccine Name: Brucella abortus S19 vjbR mutant vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0004283
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- vjbR
gene engineering:
- Type: Gene mutation
- Description: The vjbR was mutated in Brucella abortus strain 19 (Arenas-Gamboa et al., 2009).
- Detailed Gene Information: Click Here.
- Immunization Route: Intraperitoneal injection (i.p.)
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Host Response |
Mouse Response
- Persistence: An encapsulated vjbR mutant is attenuated in mice (Arenas-Gamboa et al., 2009).
- Efficacy: A single dose of an encapsulated vjbR mutant induced protection in mice from challenge with wild type Brucella (Arenas-Gamboa et al., 2009).
- Host Ighg1 response
- Description: Mouse immunization with encapsulated S19 ΔvjbR::Kan induced higher IgG1 and IgG2a levels compared to the nonencapsulated S19 ΔvjbR::Kan mutant 3 weeks post vaccination and significantly higher levels than naive mice (Arenas-Gamboa et al., 2009).
- Detailed Gene Information: Click Here.
- Host Ighv1-9 response
- Description: Mouse immunization with encapsulated S19 ΔvjbR::Kan induced higher IgG1 and IgG2a levels compared to the nonencapsulated S19 ΔvjbR::Kan mutant 3 weeks post vaccination and significantly higher levels than naive mice (Arenas-Gamboa et al., 2009).
- Detailed Gene Information: Click Here.
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References |
Arenas-Gamboa et al., 2009: Arenas-Gamboa AM, Ficht TA, Kahl-McDonagh MM, Gomez G, Rice-Ficht AC. The Brucella abortus S19 DeltavjbR live vaccine candidate is safer than S19 and confers protection against wild-type challenge in BALB/c mice when delivered in a sustained-release vehicle. Infection and immunity. 2009; 77(2); 877-884. [PubMed: 19047401].
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