|
Vaccine Detail
E. ictaluri crp mutant vaccine |
Vaccine Information |
- Vaccine Name: E. ictaluri crp mutant vaccine
- Target Pathogen: Edwardsiella ictaluri
- Target Disease: Enteric septicemia of channel catfish (ESC)
- Vaccine Ontology ID: VO_0002829
- Type: Live, attenuated vaccine
- Status: Research
- crp
gene engineering:
- Type: Gene mutation
- Description: This crp mutat is from Edwardsiella ictaluri (Santander et al., 2011).
- Detailed Gene Information: Click Here.
- Immunization Route: Intramuscular injection (i.m.)
|
Host Response |
Zebrafish Response
- Persistence: A crp mutant is attenuated in zebrafish that were immunized intramuscularly (Santander et al., 2011).
- Efficacy: A crp mutant protected zebrafish from challenge with wild type E. ictaluri six weeks after immunization (Santander et al., 2011).
Catfishes Response
- Persistence: A crp mutant is attenuated in catfish that were immunized intracoelomically (Santander et al., 2011).
- Efficacy: A crp mutant protected catfish from challenge with wild type E. ictaluri six weeks after immunization (Santander et al., 2011).
- Host IgM response
- Description: IgM titers of immersion vaccinated catfish were lower compared to i.c.-vaccinated catfish as expected. However, in both cases skin IgM titers were significantly higher than naïve non-vaccinated fish 30 days post-immunization (Santander et al., 2011).
- Detailed Gene Information: Click Here.
|
References |
Santander et al., 2011: Santander J, Mitra A, Curtiss R 3rd. Phenotype, virulence and immunogenicity of Edwardsiella ictaluri cyclic adenosine 3',5'-monophosphate receptor protein (Crp) mutants in catfish host. Fish & shellfish immunology. 2011; ; . [PubMed: 22015784].
|
|