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Vaccine Detail
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Salmonella Typhimurium wecA mutant vaccine |
| Vaccine Information |
- Vaccine Name: Salmonella Typhimurium wecA mutant vaccine
- Target Pathogen: Salmonella spp.
- Target Disease: Salmonellosis
- Vaccine Ontology ID: VO_0002914
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- wecA
gene engineering:
- Type: Gene mutation
- Description: This wecA mutant is from Salmonella Typhimurium (Gilbreath et al., 2011).
- Detailed Gene Information: Click Here.
- Immunization Route: Intraperitoneal injection (i.p.)
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| Host Response |
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Mouse Response
- Persistence: A wecA mutant (DSM645) is attenuated in C57BL/6J mice through i.p. and oral immunization (Gilbreath et al., 2011).
- Efficacy: A wecA mutant (DSM645) protects against challenge with S. typhimurium strains TML and SL1344 30 days after immunization (Gilbreath et al., 2011).
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| References |
Gilbreath et al., 2011: Gilbreath JJ, Colvocoresses Dodds J, Rick PD, Soloski MJ, Merrell DS, Metcalf ES. Enterobacterial Common Antigen Mutants of Salmonella enterica serovar Typhimurium Establish a Persistent Infection and Provide Protection Against Subsequent Lethal Challenge. Infection and immunity. 2011; ; . [PubMed: 22025511].
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