• Vaccine Name: Mycobacterium tuberculosis RD1/panCD mutant vaccine
• Target Pathogen: Mycobacterium tuberculosis
• Target Disease: Tuberculosis
• Vaccine Ontology ID: VO_0002787
• Type: Live, attenuated vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• RD1 gene engineering:
  • Type: Gene mutation
  • Description: This RD1/panCD mutant is from Mycobacterium tuberculosis (Sambandamurthy et al., 2006).
  • Detailed Gene Information: Click Here.
• panC gene engineering:
  • Type: Gene mutation
  • Description: This RD1/panCD mutant is from Mycobacterium tuberculosis (Sambandamurthy et al., 2006).
  • Detailed Gene Information: Click Here.
• panD gene engineering:
  • Type: Gene mutation
  • Description: This RD1/panCD mutant is from Mycobacterium tuberculosis (Sambandamurthy et al., 2006).
  • Detailed Gene Information: Click Here.
• Immunization Route: subcutaneous injection

Mouse Response

• Persistence: An RD1/panCD mutant is attenuated in mice (Sambandamurthy et al., 2006).
• Efficacy: An RD1/panCD mutant induces significant protection in mice from challenge with wild type M. tuberculosis (Sambandamurthy et al., 2006).
• Host Ifng (Interferon gamma) response
  • Description: At the 10-day time point, substantial increases (relative to naive mice) were detected in IFN-γ positive CD4 and CD8 lung cells taken from the vaccinated mice (Sambandamurthy et al., 2006).
  • Detailed Gene Information: Click Here.
• Information about this animal model: Mouse Model for TB research