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Vaccine Detail
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Edwardsiella tarda aroC/slyA mutant vaccine |
| Vaccine Information |
- Vaccine Name: Edwardsiella tarda aroC/slyA mutant vaccine
- Target Pathogen: Edwardsiella tarda
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Zebra fish
- slyA
gene engineering:
- Type: Gene mutation
- Description: An aroC and slyA mutant is attenuated in zebra fish. This mutant is also protective against challenge from wild type E. tarda, resulting in a relative percent survival of 80.1% (Xiao et al., 2011).
- Detailed Gene Information: Click Here.
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Fish Response
- Persistence: This aroC/slyA mutant is attenuated in zebra fish (Xiao et al., 2011).
- Efficacy: This aroC/slyA mutant is protective in zebra fish against challenge with wild type E. tarda. The percent relative survival is 80.1% (Xiao et al., 2011).
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| References |
Xiao et al., 2011: Xiao J, Chen T, Wang Q, Liu Q, Wang X, Lv Y, Wu H, Zhang Y. Search for live attenuated vaccine candidate against edwardsiellosis by mutating virulence-related genes of fish pathogen Edwardsiella tarda. Letters in applied microbiology. 2011; ; . [PubMed: 21777261].
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