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Vaccine Detail
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Burkholderia pseudomallei asd mutant vaccine |
| Vaccine Information |
- Vaccine Name: Burkholderia pseudomallei asd mutant vaccine
- Target Pathogen: Burkholderia pseudomallei
- Target Disease: Melioidosis
- Vaccine Ontology ID: VO_0002826
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- asd
gene engineering:
- Type: Gene mutation
- Description: This asd mutant is from Burkholderia pseudomallei (Norris et al., 2011).
- Detailed Gene Information: Click Here.
- Immunization Route: intranasal immunization
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| Host Response |
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Mouse Response
- Persistence: An asd mutant is highly attenuated in mice (Norris et al., 2011).
- Efficacy: An asd mutant induces protection against challenge with wild type B. pseudomallei (Norris et al., 2011).
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| References |
Norris et al., 2011: Norris MH, Propst KL, Kang Y, Dow SW, Schweizer HP, Hoang TT. The Burkholderia pseudomallei {Delta}asd mutant exhibits attenuated intracellular infectivity and imparts protection against acute inhalation melioidosis in mice. Infection and immunity. 2011; ; . [PubMed: 21807903].
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