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Vaccine Detail
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Bovine respiratory syncytial virus glycoprotein G mutant vaccine |
| Vaccine Information |
- Vaccine Name: Bovine respiratory syncytial virus glycoprotein G mutant vaccine
- Target Pathogen: Bovine Respiratory Syncytial Virus
- Target Disease: Respiratory Disease
- Vaccine Ontology ID: VO_0002951
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Cow
- glycoprotein G
gene engineering:
- Type: Gene mutation
- Description: This glycoprotein G mutant is from Bovine respiratory syncytial virus (Schmidt et al., 2002).
- Detailed Gene Information: Click Here.
- Immunization Route: intranasal immunization
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| Host Response |
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Cattle Response
- Persistence: A glycoprotein G mutant is attenuated in calves (Schmidt et al., 2002).
- Efficacy: A glycoprotein G mutant induces significant protection in calves from challenge with wild type BRSV (Schmidt et al., 2002).
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| References |
Schmidt et al., 2002: Schmidt U, Beyer J, Polster U, Gershwin LJ, Buchholz UJ. Mucosal immunization with live recombinant bovine respiratory syncytial virus (BRSV) and recombinant BRSV lacking the envelope glycoprotein G protects against challenge with wild-type BRSV. Journal of virology. 2002; 76(23); 12355-12359. [PubMed: 12414977].
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