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Vaccine Detail

Brucella abortus pgm mutant vaccine
Vaccine Information
  • Vaccine Name: Brucella abortus pgm mutant vaccine
  • Target Pathogen: Brucella spp.
  • Target Disease: Brucellosis
  • Vaccine Ontology ID: VO_0002819
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • pgm gene engineering:
    • Type: Gene mutation
    • Description: This pgm mutant is from Brucella abortus (Ugalde et al., 2003).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intraperitoneal injection (i.p.)
Host Response

Mouse Response

  • Persistence: A pgm mutant is attenuated in mice (Ugalde et al., 2003).
  • Efficacy: A pgm mutant induces significant protection in mice from challenge with wild type B. abortus (Ugalde et al., 2003).
  • Host Ifng (Interferon gamma) response
    • Description: Spleen cells from Δpgm-vaccinated mice were induced to secrete high levels of IFN-γ 8 weeks after immunization after stimulation with heat-inactivated B. abortus S2308 whole cells. The levels were compared to a positive control, the nonspecific mitogen ConA, and were significant (Ugalde et al., 2003).
    • Detailed Gene Information: Click Here.
References
Ugalde et al., 2003: Ugalde JE, Comerci DJ, Leguizamón MS, Ugalde RA. Evaluation of Brucella abortus phosphoglucomutase (pgm) mutant as a new live rough-phenotype vaccine. Infection and immunity. 2003; 71(11); 6264-6269. [PubMed: 14573645].