|
Vaccine Detail
Brucella abortus pgm mutant vaccine |
Vaccine Information |
- Vaccine Name: Brucella abortus pgm mutant vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0002819
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- pgm
gene engineering:
- Type: Gene mutation
- Description: This pgm mutant is from Brucella abortus (Ugalde et al., 2003).
- Detailed Gene Information: Click Here.
- Immunization Route: Intraperitoneal injection (i.p.)
|
Host Response |
Mouse Response
- Persistence: A pgm mutant is attenuated in mice (Ugalde et al., 2003).
- Efficacy: A pgm mutant induces significant protection in mice from challenge with wild type B. abortus (Ugalde et al., 2003).
- Host Ifng (Interferon gamma) response
- Description: Spleen cells from Δpgm-vaccinated mice were induced to secrete high levels of IFN-γ 8 weeks after immunization after stimulation with heat-inactivated B. abortus S2308 whole cells. The levels were compared to a positive control, the nonspecific mitogen ConA, and were significant (Ugalde et al., 2003).
- Detailed Gene Information: Click Here.
|
References |
Ugalde et al., 2003: Ugalde JE, Comerci DJ, Leguizamón MS, Ugalde RA. Evaluation of Brucella abortus phosphoglucomutase (pgm) mutant as a new live rough-phenotype vaccine. Infection and immunity. 2003; 71(11); 6264-6269. [PubMed: 14573645].
|
|