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Vaccine Detail

Brucella melitensis omp31 mutant vaccine

Vaccine Information

Vaccine Name: Brucella melitensis omp31 mutant vaccine
Target Pathogen: Brucella spp.
Target Disease: Brucellosis
Vaccine Ontology ID: VO_0004002
Type: Live, attenuated vaccine
Status: Research
Host Species as Laboratory Animal Model: Mouse
omp31 gene engineering:
- Type: Gene mutation
- Description: This omp31 mutant is from Brucella melitensis (Cloeckaert et al., 2004).
- Detailed Gene Information: Click Here.
Immunization Route: subcutaneous injection

Host Response

Mouse Response

Persistence: An omp31 mutant is attenuated in mice (Cloeckaert et al., 2004).
Efficacy: An omp31 mutant induces significant protection in mice from challenge with wild type B. melitensis (Cloeckaert et al., 2004).

References

Cloeckaert et al., 2004: Cloeckaert A, Jacques I, Grilló MJ, Marín CM, Grayon M, Blasco JM, Verger JM. Development and evaluation as vaccines in mice of Brucella melitensis Rev.1 single and double deletion mutants of the bp26 and omp31 genes coding for antigens of diagnostic significance in ovine brucellosis. Vaccine. 2004; 22(21-22); 2827-2835. [PubMed: 15246618].