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Vaccine Detail

Brucella melitensis omp25 mutant vaccine

Vaccine Information

Vaccine Name: Brucella melitensis omp25 mutant vaccine
Target Pathogen: Brucella spp.
Target Disease: Brucellosis
Vaccine Ontology ID: VO_0004001
Type: Live, attenuated vaccine
Status: Research
Host Species as Laboratory Animal Model: Mouse
Omp25 gene engineering:
- Type: Gene mutation
- Description: This omp25 mutant is from Brucella melitensis (Edmonds et al., 2002).
- Detailed Gene Information: Click Here.
Immunization Route: Intravenous injection (i.v.)

Host Response

Mouse Response

Persistence: An omp25 mutant is attenuated in mice (Edmonds et al., 2002).
Efficacy: An omp25 mutant induces protection from challenge with wild type Brucella melitensis (Edmonds et al., 2002).

References

Edmonds et al., 2002: Edmonds MD, Cloeckaert A, Elzer PH. Brucella species lacking the major outer membrane protein Omp25 are attenuated in mice and protect against Brucella melitensis and Brucella ovis. Veterinary microbiology. 2002; 88(3); 205-221. [PubMed: 12151196].