|
|
Vaccine Detail
|
Brucella abortus exsA mutant vaccine |
| Vaccine Information |
- Vaccine Name: Brucella abortus exsA mutant vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0002812
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- exsA
gene engineering:
- Type: Gene mutation
- Description: This exsA mutant is from Brucella abortus (Rosinha et al., 2002a).
- Detailed Gene Information: Click Here.
- Immunization Route: Intraperitoneal injection (i.p.)
|
| Host Response |
|
Mouse Response
- Persistence: Brucella DeltaexsA mutant showed decreased survival in mice compared to the survival of parental strain S2308 (Rosinha et al., 2002a).
- Efficacy: Challenge experiments revealed that the exsA mutant strain induced superior protective immunity in BALB/c mice compared to the protective immunity induced by strain S19 or RB51 (Rosinha et al., 2002a).
|
| References |
Rosinha et al., 2002a: Rosinha GM, Freitas DA, Miyoshi A, Azevedo V, Campos E, Cravero SL, Rossetti O, Splitter G, Oliveira SC. Identification and characterization of a Brucella abortus ATP-binding cassette transporter homolog to Rhizobium meliloti ExsA and its role in virulence and protection in mice. Infection and immunity. 2002; 70(9); 5036-5044. [PubMed: 12183550].
|
|
