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Vaccine Detail

Burkholderia pseudomallei purM mutant vaccine

Vaccine Information

Vaccine Name: Burkholderia pseudomallei purM mutant vaccine
Target Pathogen: Burkholderia pseudomallei
Target Disease: Melioidosis
Vaccine Ontology ID: VO_0002827
Type: Live, attenuated vaccine
Status: Research
Host Species as Laboratory Animal Model: Mouse
purM gene engineering:
- Type: Gene mutation
- Description: This purM mutant is from Burkholderia pseudomallei (Breitbach et al., 2008).
- Detailed Gene Information: Click Here.
Immunization Route: Intraperitoneal injection (i.p.)

Host Response

Mouse Response

Persistence: A purM mutant is attenuated in mice (Breitbach et al., 2008).
Efficacy: A purM mutant induced protection from challenge with wild type B. pseudomallei (Breitbach et al., 2008).

References

Breitbach et al., 2008: Breitbach K, Köhler J, Steinmetz I. Induction of protective immunity against Burkholderia pseudomallei using attenuated mutants with defects in the intracellular life cycle. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2008; 102 Suppl 1; S89-94. [PubMed: 19121696].