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Vaccine Detail

Classical swine fever virus E1 mutant vaccine

Vaccine Information

Vaccine Name: Classical swine fever virus E1 mutant vaccine
Target Pathogen: Classical swine fever virus
Target Disease: Classical swine fever, hog cholera
Vaccine Ontology ID: VO_0002953
Type: Live, attenuated vaccine
Status: Research
Host Species as Laboratory Animal Model: Pig
E1 gene engineering:
- Type: Gene mutation
- Description: This E1 mutant is from Classical swine fever virus (Fernandez-Sainz et al., 2009).
- Detailed Gene Information: Click Here.
Immunization Route: intranasal immunization

Host Response

Pig Response

Persistence: An E1 mutant is attenuated in swine (Fernandez-Sainz et al., 2009).
Efficacy: An E1 mutant induced protection in swine from challenge with wild type CSFV (Fernandez-Sainz et al., 2009).

References

Fernandez-Sainz et al., 2009: Fernandez-Sainz I, Holinka LG, Gavrilov BK, Prarat MV, Gladue D, Lu Z, Jia W, Risatti GR, Borca MV. Alteration of the N-linked glycosylation condition in E1 glycoprotein of Classical Swine Fever Virus strain Brescia alters virulence in swine. Virology. 2009; 386(1); 210-216. [PubMed: 19203774].