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Vaccine Detail

Feline herpesvirus 1 UL23 mutant vaccine

Vaccine Information

Vaccine Name: Feline herpesvirus 1 UL23 mutant vaccine
Target Pathogen: Feline herpesvirus 1
Target Disease: Feline viral rhinotracheitis
Product Name: C7301dlTK
Vaccine Ontology ID: VO_0002958
Type: Live, attenuated vaccine
Status: Research
Host Species as Laboratory Animal Model: Cat
UL23 gene engineering:
- Type: Gene mutation
- Description: This UL23 mutant is from Felid herpesvirus 1 (Yokoyama et al., 1996).
- Detailed Gene Information: Click Here.
Immunization Route: Intramuscular injection (i.m.)

Host Response

Cat Response

Persistence: A UL23 mutant is attenuated in cats (Yokoyama et al., 1996).
Efficacy: A UL23 mutant induces significant protection in cats from wild type FHV-1 4 weeks after vaccination (Yokoyama et al., 1996).

References

Yokoyama et al., 1996: Yokoyama N, Maeda K, Tohya Y, Kawaguchi Y, Shin YS, Ono M, Ishiguro S, Fujikawa Y, Mikami T. Pathogenicity and vaccine efficacy of a thymidine kinase-deficient mutant of feline herpesvirus type 1 in cats. Archives of virology. 1996; 141(3-4); 481-494. [PubMed: 8645090].