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Vaccine Detail

Feline infectiour peritonitis virus 3abc mutant vaccine

Vaccine Information

Vaccine Name: Feline infectiour peritonitis virus 3abc mutant vaccine
Target Pathogen: Feline infectious peritonitis virus
Target Disease: Feline infectious peritonitis (FIP)
Type: Live, attenuated vaccine
Status: Research
Host Species as Laboratory Animal Model: Cat
3a gene engineering:
- Type: Gene mutation
- Description: This 3abc mutant is from Feline infectious peritonitis virus (Haijema et al., 2004).
- Detailed Gene Information: Click Here.
3b gene engineering:
- Type: Gene mutation
- Description: This 3abc mutant is from Feline infectious peritonitis virus (Haijema et al., 2004).
- Detailed Gene Information: Click Here.
3c gene engineering:
- Type: Gene mutation
- Description: This 3abc mutant is from Feline infectious peritonitis virus (Haijema et al., 2004).
- Detailed Gene Information: Click Here.
Immunization Route: Oronasal immunization

Host Response

Cat Response

Persistence: A 3abc mutant is attenuated in kittens (Haijema et al., 2004).
Efficacy: A 3abc mutant induces protection in kittens from challenge with wild type FIPV (Haijema et al., 2004).

References

Haijema et al., 2004: Haijema BJ, Volders H, Rottier PJ. Live, attenuated coronavirus vaccines through the directed deletion of group-specific genes provide protection against feline infectious peritonitis. Journal of virology. 2004; 78(8); 3863-3871. [PubMed: 15047802].