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Vaccine Detail
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Francisella tularensis purMCD mutant vaccine |
| Vaccine Information |
- Vaccine Name: Francisella tularensis purMCD mutant vaccine
- Target Pathogen: Francisella tularensis
- Target Disease: Tularemia
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- PurC/PurD
gene engineering:
- Type: Gene mutation
- Description: This purMCD mutant is from Francisella tularensis (Pechous et al., 2006).
- Detailed Gene Information: Click Here.
- purM
gene engineering:
- Type: Gene mutation
- Description: This purMCD mutant is from Francisella tularensis (Pechous et al., 2006).
- Detailed Gene Information: Click Here.
- Immunization Route: Intraperitoneal injection (i.p.)
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| Host Response |
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Mouse Response
- Persistence: A purMCD mutant is attenuated in mice (Pechous et al., 2006).
- Efficacy: A purMCD mutant induces significant protection in mice from challenge with wild type F. tularensis (Pechous et al., 2006).
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| References |
Pechous et al., 2006: Pechous R, Celli J, Penoske R, Hayes SF, Frank DW, Zahrt TC. Construction and characterization of an attenuated purine auxotroph in a Francisella tularensis live vaccine strain. Infection and immunity. 2006; 74(8); 4452-4461. [PubMed: 16861631].
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