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Vaccine Detail
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Francisella tularensis FTT0918 mutant vaccine |
| Vaccine Information |
- Vaccine Name: Francisella tularensis FTT0918 mutant vaccine
- Target Pathogen: Francisella tularensis
- Target Disease: Tularemia
- Vaccine Ontology ID: VO_0002843
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- FTT0918
gene engineering:
- Type: Gene mutation
- Description: This FTT0918 mutant is from Francisella tularensis (Twine et al., 2005).
- Detailed Gene Information: Click Here.
- Immunization Route: Intradermal injection (i.d.)
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| Host Response |
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Mouse Response
- Persistence: A FTT0918 mutant showed significantly reduced virulence in mice (Twine et al., 2005).
- Efficacy: A FTT0918 provided protection in mice from challenge with wild type F. tularensis 2 months after immunization (Twine et al., 2005).
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| References |
Twine et al., 2005: Twine S, Bystrom M, Chen W, Forsman M, Golovliov I, Johansson A, Kelly J, Lindgren H, Svensson K, Zingmark C, Conlan W, Sjostedt A. A mutant of Francisella tularensis strain SCHU S4 lacking the ability to express a 58-kilodalton protein is attenuated for virulence and is an effective live vaccine. Infection and immunity. 2005 Dec; 73(12); 8345-52. [PubMed: 16299332 ].
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