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Vaccine Detail

Gallid herpesvirus 1 UL47 mutant vaccine

Vaccine Information

Vaccine Name: Gallid herpesvirus 1 UL47 mutant vaccine
Target Pathogen: Gallid herpesvirus 1
Target Disease: Avian infectious laryngotracheitis, Fowl Laryngotracheitis
Vaccine Ontology ID: VO_0002968
Type: Live, attenuated vaccine
Status: Research
Host Species as Laboratory Animal Model: Chicken
UL47 gene engineering:
- Type: Gene mutation
- Description: This UL47 mutant is from Gallid herpesvirus 1 (Helferich et al., 2007).
- Detailed Gene Information: Click Here.
Immunization Route: Intratracheal immunization

Host Response

Chicken Response

Persistence: A UL47 mutant is attenuated in chickens (Helferich et al., 2007).
Efficacy: A UL47 mutant induces significant protection in chickens from challenge with wild type GHV-1 (Helferich et al., 2007).

References

Helferich et al., 2007: Helferich D, Veits J, Teifke JP, Mettenleiter TC, Fuchs W. The UL47 gene of avian infectious laryngotracheitis virus is not essential for in vitro replication but is relevant for virulence in chickens. The Journal of general virology. 2007; 88(Pt 3); 732-742. [PubMed: 17325345].