• Vaccine Name: Hepatitis B virus X protein mutant vaccine
• Target Pathogen: Hepatitis B virus
• Target Disease: Hepatitis B
• Vaccine Ontology ID: VO_0002969
• Type: Live, attenuated vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Woodchuck
• HBVgp3 X protein gene engineering:
  • Type: Gene mutation
  • Description: .This X protein is from Hepatitis B virus (Zhang et al., 2001).
  • Detailed Gene Information: Click Here.
• Immunization Route: Intrahepatic immunization

Woodchuck Response

• Persistence: An X protein mutant is attenuated in woodchucks (Zhang et al., 2001).
• Efficacy: An X protein mutant induces significant protection in woodchucks from challenge with wild type Hepatitis B virus (Zhang et al., 2001).