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Vaccine Detail

Herpes simplex virus 1 TK mutant vaccine

Vaccine Information

Vaccine Name: Herpes simplex virus 1 TK mutant vaccine
Target Pathogen: Herpes simplex virus type 1 and 2
Target Disease: Herpes
Vaccine Ontology ID: VO_0002973
Type: Live, attenuated vaccine
Status: Research
Host Species as Laboratory Animal Model: Mouse
TK gene engineering:
- Type: Gene mutation
- Description: This TK mutant is from human herpesvirus type 1 (Field and Wildy, 1978).
- Detailed Gene Information: Click Here.
Immunization Route: Intracerebral immunization

Host Response

Mouse Response

Persistence: A TK mutant is attenuated in mice (Field and Wildy, 1978).
Efficacy: A TK mutant induces significant protection from challenge with wild type HSV-1 (Field and Wildy, 1978).

References

Field and Wildy, 1978: Field HJ, Wildy P. The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice. The Journal of hygiene. 1978; 81(2); 267-277. [PubMed: 212476].