|
|
Vaccine Detail
|
Human metapneumovirus M2-2 mutant vaccine |
| Vaccine Information |
- Vaccine Name: Human metapneumovirus M2-2 mutant vaccine
- Target Pathogen: Human metapneumovirus
- Target Disease: Respiratory tract infection
- Vaccine Ontology ID: VO_0002977
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: African green monkeys
- M2-2
gene engineering:
- Type: Gene mutation
- Description: This M2-2 mutant is from Human metapneumovirus (Biacchesi et al., 2005).
- Detailed Gene Information: Click Here.
- Immunization Route: intranasal immunization
|
| Host Response |
|
Monkey Response
- Persistence: An M2-2 mutant is attenuated in African green monkeys (Biacchesi et al., 2005).
- Efficacy: An M2-2 mutant induces significant protection in African green monkeys from challenge with wild type HMPV (Biacchesi et al., 2005).
|
| References |
Biacchesi et al., 2005: Biacchesi S, Pham QN, Skiadopoulos MH, Murphy BR, Collins PL, Buchholz UJ. Infection of nonhuman primates with recombinant human metapneumovirus lacking the SH, G, or M2-2 protein categorizes each as a nonessential accessory protein and identifies vaccine candidates. Journal of virology. 2005; 79(19); 12608-12613. [PubMed: 16160190].
|
|
