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Vaccine Detail
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Human metapneumovirus G protein mutant vaccine |
| Vaccine Information |
- Vaccine Name: Human metapneumovirus G protein mutant vaccine
- Target Pathogen: Human metapneumovirus
- Target Disease: Respiratory tract infection
- Vaccine Ontology ID: VO_0002976
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: African green monkey
- G protein
gene engineering:
- Type: Gene mutation
- Description: This G protein is from Human metapneumovirus (Biacchesi et al., 2005).
- Detailed Gene Information: Click Here.
- Immunization Route: intranasal immunization
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| Host Response |
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Monkey Response
- Persistence: A G protein mutant is attenuated in African green monkeys (Biacchesi et al., 2005).
- Efficacy: A G protein mutant induces significant protection in African green monkeys from challenge with wild type HMPV (Biacchesi et al., 2005).
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| References |
Biacchesi et al., 2005: Biacchesi S, Pham QN, Skiadopoulos MH, Murphy BR, Collins PL, Buchholz UJ. Infection of nonhuman primates with recombinant human metapneumovirus lacking the SH, G, or M2-2 protein categorizes each as a nonessential accessory protein and identifies vaccine candidates. Journal of virology. 2005; 79(19); 12608-12613. [PubMed: 16160190].
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