• Vaccine Name: Influenza virus NS1 mutant vaccine
• Target Pathogen: Influenza virus
• Target Disease: Influenza (flu)
• Vaccine Ontology ID: VO_0002981
• Type: Live, attenuated vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse, pig, horse, macaque
• NS1 from Influenza virus gene engineering:
  • Type: Gene mutation
  • Description: This NS1 mutant is from influenza virus (Richt and García-Sastre, 2009).
  • Detailed Gene Information: Click Here.
• Immunization Route: intranasal immunization

Mouse Response

• Persistence: An NS1 mutant is attenuated in mice (Richt and García-Sastre, 2009).
• Efficacy: An NS1 mutant induces significant protection in mice from challenge with wild type influenza virus (Richt and García-Sastre, 2009).

Pig Response

• Persistence: An NS1 mutant is attenuated in pigs (Richt and García-Sastre, 2009).
• Efficacy: An NS1 mutant induces significant protection in pigs from challenge with wild type influenza virus (Richt and García-Sastre, 2009).

Horse Response

• Persistence: An NS1 mutant is attenuated in horses (Richt and García-Sastre, 2009).
• Efficacy: An NS1 mutant induces significant protection in horses from challenge with wild type influenza virus (Richt and García-Sastre, 2009).

Macaque Response

• Persistence: An NS1 mutant is attenuated in macaques (Richt and García-Sastre, 2009).
• Efficacy: An NS1 mutant induces significant protection in macaques from challenge with wild type influenza virus (Richt and García-Sastre, 2009).