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Vaccine Detail

Mycobacterium tuberculosis panCD mutant vaccine

Vaccine Information

Vaccine Name: Mycobacterium tuberculosis panCD mutant vaccine
Target Pathogen: Mycobacterium tuberculosis
Target Disease: Tuberculosis
Vaccine Ontology ID: VO_0002786
Type: Live, attenuated vaccine
Status: Research
Host Species as Laboratory Animal Model: Mouse
panC gene engineering:
- Type: Gene mutation
- Description: This panCD mutant is from Mycobacterium tuberculosis (Sambandamurthy et al., 2002).
- Detailed Gene Information: Click Here.
panD gene engineering:
- Type: Gene mutation
- Description: This panCD mutant is from Mycobacterium tuberculosis (Sambandamurthy et al., 2002).
- Detailed Gene Information: Click Here.
Immunization Route: subcutaneous injection

Host Response

Mouse Response

Persistence: A panCD mutant is attenuated in mice (Sambandamurthy et al., 2002).
Efficacy: A panCD mutant induces significant protection in mice from challenge with wild type M. tuberculosis (Sambandamurthy et al., 2002).
Information about this animal model: Mouse Model for TB research

References

Sambandamurthy et al., 2002: Sambandamurthy VK, Wang X, Chen B, Russell RG, Derrick S, Collins FM, Morris SL, Jacobs WR Jr. A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis. Nature medicine. 2002; 8(10); 1171-1174. [PubMed: 12219086].