• Vaccine Name: Mycobacterium tuberculosis mce-2 mutant vaccine
• Target Pathogen: Mycobacterium tuberculosis
• Target Disease: Tuberculosis
• Vaccine Ontology ID: VO_0004279
• Type: Live, attenuated vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• mce-2 gene engineering:
  • Type: Gene mutation
  • Description: This mce-2 mutant is from Mycobacterium tuberculosis (Aguilar et al., 2006).
  • Detailed Gene Information: Click Here.
• mce-3 gene engineering:
  • Type: Gene mutation
  • Description: This mce-2/mce-3 mutant is from Mycobacterium tuberculosis (Aguilar et al., 2006).
  • Detailed Gene Information: Click Here.
• Immunization Route: subcutaneous injection

Mouse Response

• Persistence: A mce-2 mutant is attenuated in mice (Aguilar et al., 2006).
• Efficacy: A mce-2 mutant induces significant protection in mice from challenge with wild type M. tuberculosis (Aguilar et al., 2006).
• Host Ifng (Interferon gamma) response
  • Description: Mutant mce-2 induced a lower but progressive expression of IFN-γ than the parent strain in mice, peaking at day 120 post-infection. The IFN-gamma response in lungs was significantly lower in mice immunized with mce-2 mutants on days 1, 3, 7, 14, and 21 days post infection as compared to mice infected with the wild type (Aguilar et al., 2006).
  • Detailed Gene Information: Click Here.
• Host Il4 (interleukin 4) response
  • Description: The mce-2 mutant maintained low IL-4 expression until day 60 post-infection, showing slight increase at day 120. The expression of IL-4 was higher in the lungs of mice infected with the parental strain. Infection with the wild type strain induced significantly more IL-4 than that induced by immunization with the mutant on days 21, 28, and 60 post infection (Aguilar et al., 2006).
  • Detailed Gene Information: Click Here.
• Information about this animal model: Mouse Model for TB research