• Vaccine Name: Neisseria meningitidis metH/siaD mutant vaccine
• Target Pathogen: Neisseria meningitidis
• Target Disease: Meningitis
• Type: Live, attenuated vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• metH gene engineering:
  • Type: Gene mutation
  • Description: This metH/siaD mutant is from Neisseria meningitidis (Li et al., 2004).
  • Detailed Gene Information: Click Here.
• siaD gene engineering:
  • Type: Gene mutation
  • Description: This metH/siaD mutant is from Neisseria meningitidis (Li et al., 2004).
  • Detailed Gene Information: Click Here.
• siaD gene engineering:
  • Type: Gene mutation
  • Description: This metH/siaD mutant is from Neisseria meningitidis (Li et al., 2004).
  • Detailed Gene Information: Click Here.
• Immunization Route: Intraperitoneal injection (i.p.)

Mouse Response

• Persistence: A metH/siaD mutant is attenuated in mice (Li et al., 2004).
• Efficacy: A metH/siaD mutant induces significant protection in mice from challenge with wild type neisseria meningitidis (Li et al., 2004).