• Vaccine Name: Pasteurella multocida aroA mutant vaccine
• Target Pathogen: Pasteurella multocida
• Target Disease: Pasteurellosis, fowl cholera
• Vaccine Ontology ID: VO_0002862
• Type: Live, attenuated vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Cow
• aroA gene engineering:
  • Type: Gene mutation
  • Description: This aroA mutant is from Pasteurella multocida (Dagleish et al., 2007).
  • Detailed Gene Information: Click Here.
• Immunization Route: Intramuscular injection (i.m.)

Cattle Response

• Persistence: An aroA mutant is highly attenuated in calves (Dagleish et al., 2007).
• Efficacy: An aroA mutant induces significant protection in calves from challenge with wild type Pasteurella multocida (Dagleish et al., 2007).
• Host IgG response
  • Description: After second vaccination, serum IgG titers rose. Groups receiving 10^9 and 10^8 CFU of the mutant had significantly higher titer of IgG than those receiving 10^7 CFU, and all vaccinated groups had significantly higher titers than the unvaccinated challenge control group of calves (Dagleish et al., 2007).
  • Detailed Gene Information: Click Here.
• Host IgM response
  • Description: After the second vaccination, serum IgM titers rose. Groups receiving 10^9 and 10^8 CFU of the mutant had significantly higher titer of IgM than those receiving 10^7 CFU, and all vaccinated groups had significantly higher titers than the unvaccinated challenge control group of calves (Dagleish et al., 2007).
  • Detailed Gene Information: Click Here.