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Vaccine Detail
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Plasmodium FabB/FabF mutant vaccine |
| Vaccine Information |
- Vaccine Name: Plasmodium FabB/FabF mutant vaccine
- Target Pathogen: Plasmodium spp.
- Target Disease: Malaria
- Vaccine Ontology ID: VO_0003007
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- FabB/FabF
gene engineering:
- Type: Gene mutation
- Description: This FabB/FabF mutant is from Plasmodium (Butler et al., 2011).
- Detailed Gene Information: Click Here.
- Immunization Route: Intravenous injection (i.v.)
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| Host Response |
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Mouse Response
- Persistence: A FabB/FabF genetically attenuated parasite is attenuated in mice (Butler et al., 2011).
- Efficacy: A FabB/FabF genetically attenuated parasite induces complete protection in mice from challenge with wild type Plasmodium (Butler et al., 2011).
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| References |
Butler et al., 2011: Butler NS, Schmidt NW, Vaughan AM, Aly AS, Kappe SH, Harty JT. Superior antimalarial immunity after vaccination with late liver stage-arresting genetically attenuated parasites. Cell host & microbe. 2011; 9(6); 451-462. [PubMed: 21669394].
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