|
|
Vaccine Detail
|
Pseudorabies virus US3 mutant vaccine |
| Vaccine Information |
- Vaccine Name: Pseudorabies virus US3 mutant vaccine
- Target Pathogen: Pseudorabies virus
- Target Disease: Aujeszky's disease
- Vaccine Ontology ID: VO_0002990
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Pig
- US3
gene engineering:
- Type: Gene mutation
- Description: This US3 mutant is from Suid herpesvirus 1 (Kimman et al., 1994).
- Detailed Gene Information: Click Here.
- Immunization Route: intranasal immunization
|
| Host Response |
|
Pig Response
- Persistence: A US3 mutant is attenuated in pigs (Kimman et al., 1994).
- Efficacy: A US3 mutant induces complete protection in pigs from challenge with wild type Pseudorabies virus (Kimman et al., 1994).
|
| References |
Kimman et al., 1994: Kimman TG, De Wind N, De Bruin T, de Visser Y, Voermans J. Inactivation of glycoprotein gE and thymidine kinase or the US3-encoded protein kinase synergistically decreases in vivo replication of pseudorabies virus and the induction of protective immunity. Virology. 1994; 205(2); 511-518. [PubMed: 7975253].
|
|
