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Vaccine Detail

Pseudorabies virus glycoprotein E/G/UL23 mutant vaccine
Vaccine Information
  • Vaccine Name: Pseudorabies virus glycoprotein E/G/UL23 mutant vaccine
  • Target Pathogen: Pseudorabies virus
  • Target Disease: Aujeszky's disease
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Raccoon
  • glycoprotein G gene engineering:
    • Type: Gene mutation
    • Description: This glycoprotein E/G/UL23 mutant is from Suid herpesvirus 1 (Weigel et al., 2003).
    • Detailed Gene Information: Click Here.
  • glycoprotein E gene engineering:
    • Type: Gene mutation
    • Description: This glycoprotein E/G/UL23 mutant is from Suid herpesvirus 1 (Weigel et al., 2003).
    • Detailed Gene Information: Click Here.
  • UL23 gene engineering:
    • Type: Gene mutation
    • Description: This glycoprotein E/G/UL23 mutant is from Suid herpesvirus 1 (Weigel et al., 2003).
    • Detailed Gene Information: Click Here.
  • Immunization Route: intranasal immunization
Host Response

Raccoon Response

  • Persistence: A glycoprotein E/G/UL23 is attenuated in raccoons (Weigel et al., 2003).
  • Efficacy: A glycoprotein E/G/UL23 mutant provides some protection in raccoons from challenge with wild type Pseudorabies virus (Weigel et al., 2003).
References
Weigel et al., 2003: Weigel RM, Hahn EC, Scherba G. Survival and immunization of raccoons after exposure to pseudorabies (Aujeszky's disease) virus gene-deleted vaccines. Veterinary microbiology. 2003; 92(1-2); 19-24. [PubMed: 12488067].