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Vaccine Detail

Rabies virus P protein mutant vaccine

Vaccine Information

Vaccine Name: Rabies virus P protein mutant vaccine
Target Pathogen: Rabies virus
Target Disease: Rabies
Vaccine Ontology ID: VO_0002992
Type: Live, attenuated vaccine
Status: Research
Host Species as Laboratory Animal Model: Mouse
P protein gene engineering:
- Type: Gene mutation
- Description: This P protein mutant is from rabies virus (Morimoto et al., 2005).
- Detailed Gene Information: Click Here.
Immunization Route: Intracranial immunization

Host Response

Mouse Response

Persistence: A P protein mutant is attenuated in mice (Morimoto et al., 2005).
Efficacy: A P protein mutant induces protection in mice from challenge with wild type rabies virus (Morimoto et al., 2005).

References

Morimoto et al., 2005: Morimoto K, Shoji Y, Inoue S. Characterization of P gene-deficient rabies virus: propagation, pathogenicity and antigenicity. Virus research. 2005; 111(1); 61-67. [PubMed: 15896403].