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Vaccine Detail
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Rabies virus glycoprotein G mutant vaccine |
| Vaccine Information |
- Vaccine Name: Rabies virus glycoprotein G mutant vaccine
- Target Pathogen: Rabies virus
- Target Disease: Rabies
- Vaccine Ontology ID: VO_0002991
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse, hamster
- Glycoprotein G
gene engineering:
- Type: Gene mutation
- Description: This glycoprotein G mutant is from Rabies virus (Wu et al., 2011).
- Detailed Gene Information: Click Here.
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Persistence: A glycoprotein G mutant is attenuated in mice (Wu et al., 2011).
- Efficacy: A glycoprotein G mutant induces protection in mice from challenge with wild type rabies virus (Wu et al., 2011).
Hamster Response
- Persistence: A glycoprotein G mutant is attenuated in hamsters (Wu et al., 2011).
- Efficacy: A glycoprotein G mutant induces significant protection in hamsters from challenge with wild type rabies virus (Wu et al., 2011).
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| References |
Wu et al., 2011: Wu X, Franka R, Henderson H, Rupprecht CE. Live attenuated rabies virus co-infected with street rabies virus protects animals against rabies. Vaccine. 2011; ; . [PubMed: 21514343].
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