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Vaccine Detail

Salmonella Typhimurium znuABC mutant vaccine

Vaccine Information

Vaccine Name: Salmonella Typhimurium znuABC mutant vaccine
Target Pathogen: Salmonella spp.
Target Disease: Salmonellosis
Type: Live, attenuated vaccine
Status: Research
Host Species as Laboratory Animal Model: Mouse
znuA gene engineering:
- Type: Gene mutation
- Description: This znuABC mutant is from Salmonella Typhimurium (Pesciaroli et al., 2011).
- Detailed Gene Information: Click Here.
znuB gene engineering:
- Type: Gene mutation
- Description: This znuABC mutant is from Salmonella Typhimurium (Pesciaroli et al., 2011).
- Detailed Gene Information: Click Here.
znuC gene engineering:
- Type: Gene mutation
- Description: This znuABC mutant is from Salmonella Typhimurium (Pesciaroli et al., 2011).
- Detailed Gene Information: Click Here.
Immunization Route: Oral immunization

Host Response

Mouse Response

Persistence: A znuABC mutant is attenuated in mice (Pesciaroli et al., 2011).
Efficacy: A znuABC mutant induces protection in mice from challenge with wild type Salmonella Typhimurium (Pesciaroli et al., 2011).

References

Pesciaroli et al., 2011: Pesciaroli M, Aloisio F, Ammendola S, Pistoia C, Petrucci P, Tarantino M, Francia M, Battistoni A, Pasquali P. An attenuated Salmonella enterica serovar Typhimurium strain lacking the ZnuABC transporter induces protection in a mouse intestinal model of Salmonella infection. Vaccine. 2011; ; . [PubMed: 21219981].